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The C (minor) allele is associated with:

  • Increased levels of STAT3 protein.
  • 2.5X more likely to have fatty liver disease (R).

The A (major) allele is associated with:

  • Decreased levels of STAT3 protein. 

rs9891119

Parent Gene: STAT3
Importance: 3
Minor Allele: C = 39%
Major Allele: A = 61%
My Genotype: Log In
Risk Allele: A, C

Disease/Trait: Crohn's Disease

The A allele of rs9891119 is reported to be associated with Crohn'S Disease(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Crohn's disease.

Reported risk allele frequency: None
Reported genes: STAT3
Odds ratio: 1.37
Risk Allele: A (P=2.00*10-15)
Context: intron_variant
Study title: A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. (R)
Initial sample size: 372 Japanese ancestry cases,3,389 Japanese ancestry controls
Replication sample size: Up to 1,151 Japanese ancestry cases, up to 15,800 Japanese ancestry controls
Journal: Gastroenterology (R)
Year published: Dec. 21, 2012
Strength of evidence: Strong

Disease/Trait: Multiple Sclerosis

The C allele of rs9891119 is reported to be associated with Multiple Sclerosis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Multiple sclerosis.

Reported risk allele frequency: None
Reported genes: STAT3
Odds ratio: 1.11
Risk Allele: C (P=2.00*10-10)
Context: intron_variant
Study title: Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (R)
Initial sample size: 9,772 European ancestry cases, 16,849 European ancestry controls
Replication sample size: 4,218 European ancestry cases, 7,296 European ancestry controls
Journal: Nature (R)
Year published: Aug. 11, 2011
Strength of evidence: Strong