Mechanism:

  • The SNP causes lower levels of functioning in ABCC2 (R). 

  • ABCC2 is an important channeling protein that removes materials from cells and stops them from accumulating. A lower level of functioning ABCC2 causes these materials to accumulate in the body (R).

The A (minor) allele is associated with:

  • Decreased overall survival rate in stage IV non-small-lung cancer patients treated with platinum chemotherapeutics (R).

  • Another SNP, rs17222723 (R).

  • Increased risk of developing congestive heart failure (CHF) in hematopoietic cell transplantation survivors (R). This may be due to improper metabolism of anthracyclines that the patients were exposed to during treatment.

  • Increased risk of cholestatic liver disease (R).

  • Increased risk of nonalcoholic fatty liver disease (R).

  • Increased risk of cardiotoxicity in patients taking doxorubicin (a chemotherapy drug) (R).

  • Increased activity of new chemotherapy drug Flavopiridol (increased drug pharmacokinetics)(R).

  • Increased accumulation of Lopinavir (LPV) in the blood of HIV patients being treated with the drug (R). The effects of this accumulation are yet to be discovered.

     

rs8187710

Parent Gene: ABCC2

Importance: 5
Less common allele: A = 7%
More common allele: G = 93%
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