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Mechanism:

  • Increased cannabinoid binding activity (AA) [R]
  • Higher levels of cannabinoid receptor protein (A) [R]
  • Lower levels of cannabinoid receptor through altered gene transcription and mRNA stability (G) [R]

The Minor "G" allele is associated with:

  • longer gaze period for happy faces in European high school students [R]
  • higher risk of antipsychotic drug resistance in schizophrenic patients [R]
  • lower risk of marijuana addiction in adolescent marijuana users [R]

The Major "A" allele is associated with:

  • higher risk of marijuana dependence in young adults [R]
  • increased risk of nicotine addiction in Italian individuals [R]
  • increased risk of schizophrenia in marijuana users [R]
  • increased alcohol use and unsafe sex in young adults [R]
  • high cocaine and opioid drug use in African Americans [R]

This SNP is associated with (unknown which alleles):

  • Depression and anxiety [R, R2]

rs806380

Parent Gene: CNR1

Importance: 2
Minor Allele: G = 20%
Major Allele: A = 80%
My Genotype: Log In