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Mechanism:

  • T (minor) allele may cause higher levels of CRN1 protein in the body [R].
  • Cannabinoids slow stomach emptying in females and increases fasting stomach volume in males (R). The T allele is associated with this, which further supports its 'pro' CNR1 activation effects.

The  Minor "T" allele carriers:

  • Gained about 2.2 kg (4.9 pounds) more weight (CT/TT vs CC) [R].
  • Have increased risk of childhood obesity (R)
  • Have increased antipsychotic-induced weight gain (R)
  • Have larger stomach volume (TT vs CC) (R).
  • Have increased fasting stomach volume (CT/TT vs CC) [R].
  • Reduced fullness after eating [R].
  • Moved food slightly more slowly through the colon into the anus (CT/TT vsCC) [R].

This SNP is also associated with (unknown alleles):

  • Irritable Bowel Syndrome-Diarrhea (IBS-D) [R] and Irritable Bowel Syndrome- Alternating (IBS-A) [R].
  • substance dependence. [R]

rs806378

Parent Gene: CNR1

Importance: 3
Minor Allele: T = 17%
Major Allele: C = 83%
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