The Minor "C" allele is associated with:

• Lower openness on Big 5 personality [R].

• Higher risk of nicotine dependence [R].

• Lower risk of PTSD, in individuals who also have the “C” allele present at separate SNPs Rs1049353. [R]

• Impulsive behavior, based on a study using the Eysenck Personality scale [R].

• Higher waist to hip ratio, as a measurement of obesity. [R]

• Reduced risk of Preeclampsia (a pregnancy-related condition resulting in malformation and often death) in C/C individuals. [R]

• Women with the C/C genotype are 8 times more likely to contract Polycystic Ovary Syndrome. [R]

• Cannabis users with the “C” allele are 5.4 times more likely to be “frequent/persistent” users. [R]

The Major "T" allele is associated with:

• Increased risk for alcohol and drug dependence, in individuals with the T/T genotype, where there is also the G/G or G/T genotype at separate SNP Rs6454674 [R].  

• Higher risk of post-traumatic-stress disorder (PTSD) in individuals who also have “A” allele present at separate SNP Rs1049353. [R]

• Increased risk for nicotine dependence in women who also have the “A” allele at both Rs12023239 and Rs12720071. [R]

• Increased cocaine addiction in individuals with the T/T genotype, where there is also the G/G or G/T genotype at separate SNP Rs6454674 [R].

• Increased risk for cocaine addiction in African Americans [R][R].

• Poor response to antidepressants and reduced likelihood of remission in T/T individuals with Major Depressive Disorder. [R]

This SNP (unknown which alleles) is associated with :

• The risk of cannabis (Marijuana) dependence. [R]