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rs78378222

Parent Gene: TP53
Importance: 3
Minor Allele: G = 0%
Major Allele: T = 100%
My Genotype: Log In
Risk Allele: T, G, G, G, G, C, G, G

Disease/Trait: Pulse Pressure Measurement

The T allele of rs78378222 is reported to be associated with Pulse Pressure Measurement(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Pulse pressure.

Reported risk allele frequency: 99.00%
Reported genes: TP53
Beta coefficient: 0.904 unit increase
Risk Allele: T (P=2.00*10-10)
Context: 3_prime_UTR_variant
Study title: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. (R)
Initial sample size: 140,886 European ancestry individuals
Replication sample size: 190,318 European ancestry individuals
Journal: Nat Genet (R)
Year published: Jan. 30, 2017
Strength of evidence: Strong

Disease/Trait: Glioma

The G allele of rs78378222 is reported to be associated with Glioma. Your genotype was not identified for this SNP so we are unable to comment on your association with Non-glioblastoma glioma.

Reported risk allele frequency: 1.30%
Reported genes: TP53
Odds ratio: 2.73
Risk Allele: G (P=5.00*10-27)
Context: 3_prime_UTR_variant
Study title: Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. (R)
Initial sample size: 5,819 European ancestry cases, 18,190 European ancestry controls.
Replication sample size:
Journal: Nat Genet (R)
Year published: March 27, 2017
Strength of evidence: Strong

Disease/Trait: Central Nervous System Cancer

The G allele of rs78378222 is reported to be associated with Central Nervous System Cancer(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Non-glioblastoma glioma.

Reported risk allele frequency: 1.30%
Reported genes: TP53
Odds ratio: 2.73
Risk Allele: G (P=5.00*10-27)
Context: 3_prime_UTR_variant
Study title: Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. (R)
Initial sample size: 5,819 European ancestry cases, 18,190 European ancestry controls.
Replication sample size:
Journal: Nat Genet (R)
Year published: March 27, 2017
Strength of evidence: Strong

Disease/Trait: Glioblastoma Multiforme

The G allele of rs78378222 is reported to be associated with Glioblastoma Multiforme(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Glioblastoma.

Reported risk allele frequency: 1.30%
Reported genes: TP53
Odds ratio: 2.63
Risk Allele: G (P=5.00*10-29)
Context: 3_prime_UTR_variant
Study title: Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. (R)
Initial sample size: 6,191 European ancestry cases, 18,190 European ancestry controls.
Replication sample size:
Journal: Nat Genet (R)
Year published: March 27, 2017
Strength of evidence: Strong

Disease/Trait: Central Nervous System Cancer

The G allele of rs78378222 is reported to be associated with Central Nervous System Cancer(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Glioblastoma.

Reported risk allele frequency: 1.30%
Reported genes: TP53
Odds ratio: 2.63
Risk Allele: G (P=5.00*10-29)
Context: 3_prime_UTR_variant
Study title: Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. (R)
Initial sample size: 6,191 European ancestry cases, 18,190 European ancestry controls.
Replication sample size:
Journal: Nat Genet (R)
Year published: March 27, 2017
Strength of evidence: Strong

Disease/Trait: Glioma

The G allele of rs78378222 is reported to be associated with Glioma. Your genotype was not identified for this SNP so we are unable to comment on your association with Glioma.

Reported risk allele frequency: 1.30%
Reported genes: TP53
Odds ratio: 2.53
Risk Allele: G (P=9.00*10-38)
Context: 3_prime_UTR_variant
Study title: Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. (R)
Initial sample size: 12,469 European ancestry cases, 18,190 European ancestry controls.
Replication sample size:
Journal: Nat Genet (R)
Year published: March 27, 2017
Strength of evidence: Strong

Disease/Trait: Central Nervous System Cancer

The G allele of rs78378222 is reported to be associated with Central Nervous System Cancer(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Glioma.

Reported risk allele frequency: 1.30%
Reported genes: TP53
Odds ratio: 2.53
Risk Allele: G (P=9.00*10-38)
Context: 3_prime_UTR_variant
Study title: Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. (R)
Initial sample size: 12,469 European ancestry cases, 18,190 European ancestry controls.
Replication sample size:
Journal: Nat Genet (R)
Year published: March 27, 2017
Strength of evidence: Strong

Disease/Trait: Basal Cell Carcinoma

The G allele of rs78378222 is reported to be associated with Basal Cell Carcinoma(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Basal cell carcinoma.

Reported risk allele frequency: 1.00%
Reported genes: TP53
Odds ratio: 1.41
Risk Allele: G (P=2.00*10-10)
Context: 3_prime_UTR_variant
Study title: Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. (R)
Initial sample size: 12.945 European ancestry cases, 274,252 European ancestry controls
Replication sample size: 4,242 European ancestry cases, 12,802 European ancestry controls
Journal: Nat Commun (R)
Year published: Aug. 19, 2016
Strength of evidence: Strong

Disease/Trait: Basal Cell Carcinoma

The C allele of rs78378222 is reported to be associated with Basal Cell Carcinoma(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Basal cell carcinoma.

Reported risk allele frequency: None
Reported genes: TP53
Odds ratio: 2.16
Risk Allele: C (P=2.00*10-20)
Context: 3_prime_UTR_variant
Study title: A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. (R)
Initial sample size: 2,121 European ancestry cases, 39,614 European ancestry controls
Replication sample size: 2,506 European and other ancestry cases, 15,101 European and other ancestry controls
Journal: Nat Genet (R)
Year published: Sept. 25, 2011
Strength of evidence: Strong

Disease/Trait: Basal Cell Carcinoma

The G allele of rs78378222 is reported to be associated with Basal Cell Carcinoma(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Basal cell carcinoma.

Reported risk allele frequency: 1.80%
Reported genes: TP53
Odds ratio: 2.07
Risk Allele: G (P=1.00*10-20)
Context: 3_prime_UTR_variant
Study title: New basal cell carcinoma susceptibility loci. (R)
Initial sample size: 4,572 European ancestry cases, 266,358 European ancestry controls
Replication sample size: up to 956 European ancestry cases, up to 4,214 European ancestry controls, 526 cases, 528 controls
Journal: Nat Commun (R)
Year published: April 9, 2015
Strength of evidence: Strong

Disease/Trait: Basal Cell Carcinoma

The G allele of rs78378222 is reported to be associated with Basal Cell Carcinoma(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Basal cell carcinoma.

Reported risk allele frequency: None
Reported genes: TP53
Odds ratio: 2.24
Risk Allele: G (P=4.00*10-22)
Context: 3_prime_UTR_variant
Study title: Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. (R)
Initial sample size: 4,208 European ancestry cases, 109,408 European ancestry controls
Replication sample size: up to 1,480 European ancestry cases, up to 4,610 European ancestry controls
Journal: Hum Mol Genet (R)
Year published: Jan. 8, 2014
Strength of evidence: Strong