The Major "C" allele is associated with:

Alzheimer's Disease

CC = Bad version = contributes to APOE4  when combined with CC or CT genotype for rs429358.

  • rs429358 (C;C) + rs7412 (C;C) = APOE4/APOE4 (Bad) = 12x for late-onset Alzheimer's and 61x for early-onset disease [R].

  • rs429358 (C;T) + rs7412 (C;C) = APOE3/APOE4 (Bad) = >3x increased risk for Alzheimer's; 1.4x increased risk for heart disease  [R].

  • rs429358 (T;T) + rs7412 (C;C) = APOE3/APOE3 (Good), most common

  • If the allele of this SNP is "C" and the same chromosome also harbors the rs429358 "C" allele, the combination is known as an APOE-ε4 allele. The APOE-ε4 allele has a strong influence on the risk of Alzheimer's disease.

  • Many studies have estimated the level of risk, and it varies depending on age, sex, ethnicity, and other factors. One meta-analysis estimated the odds ratios for rs429358 (C;C) and rs7412 (C;C) individuals, compared to the more common rs429358 (T;T) and rs7412 (C;C) (ApoE3/ApoE3) homozygotes, to be 12x for late-onset Alzheimer's and 61x for early-onset disease [R]. 

  • Meta-analyses have also supported the association between the APOE-ε4 allele and somewhat increased risk for heart disease, with an odds ratio of 1.42 (CI: 1.26 - 1.61) [R].

 

The Minor "T" allele is associated with:

Decreased Alzheimer's risk.

  • When rs7412 and rs429358 are both T (for the two SNPs located on the same chromosome) this is known as the APOE2 allele. APOE2 indicates a reduced risk of Alzheimer's disease.

rs7412

Parent Gene: APOE

Importance: 5
Less common allele: T = 8%
More common allele: C = 92%
My Genotype: Log In
Risk Allele: C, T, T, T, T, T, T, T, T, T

Disease/Trait: Lipid Measurement

rs7412 is associated with Lipid Measurement (R) . It is reported to have a 0.75 unit decrease on Lipid metabolism phenotypes (L-LDL-FC). No specific risk allele was identified in the study.

Disease/Trait: Ldl Cholesterol Change Measurement

rs7412 is associated with Ldl Cholesterol Change Measurement . It is reported to have a 6.2 mg/dL decrease on Response to statins (LDL cholesterol change) (baseline LDL-C). No specific risk allele was identified in the study.

Disease/Trait: Response To Statin

rs7412 is associated with Response To Statin (R) . It is reported to have a 6.2 mg/dL decrease on Response to statins (LDL cholesterol change) (baseline LDL-C). No specific risk allele was identified in the study.

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

rs7412 is associated with Low Density Lipoprotein Cholesterol Measurement (R) . It is reported to have a 12.3 mg/dL decrease on LDL cholesterol. No specific risk allele was identified in the study.

Disease/Trait: Total Cholesterol Measurement

The C allele of rs7412 is reported to be associated with Total Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholesterol, total.

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

The T allele of rs7412 is reported to be associated with Low Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lipid traits (LDL-C).

Disease/Trait: Total Cholesterol Measurement

The T allele of rs7412 is reported to be associated with Total Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Lipid traits (TC).

Disease/Trait: Clinical And Behavioural Ideal Cardiovascular Health

rs7412 is associated with Clinical And Behavioural Ideal Cardiovascular Health . It is reported to association with Ideal cardiovascular health (clinical and behavioural). No specific risk allele was identified in the study.

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The T allele of rs7412 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with HDL cholesterol.

Disease/Trait: Total Cholesterol Measurement

The T allele of rs7412 is reported to be associated with Total Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholesterol, total.

Disease/Trait: Ldl Cholesterol Change Measurement

The T allele of rs7412 is reported to be associated with Ldl Cholesterol Change Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with LDL cholesterol levels.

Disease/Trait: Pulse Pressure Measurement

The T allele of rs7412 is reported to be associated with Pulse Pressure Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Pulse pressure.