The Minor "T" allele is associated with:

  • T allele is likely to cause Alzheimer's disease.

The Major "C" allele is associated with:

  • Significant weight gain compared to TT.

rs7412

Name: Need main APOE4 to be CC.
Minor Allele: T
Major Allele: C
Parent Gene: APOE
My Genotype: Log In
MAF: 0.08

Disease/Trait: Total Cholesterol Measurement

Total cholesterol measurement (P=8.00*10-239)
Risk Allele: C
Reported risk allele frequency: 93.00%
Impact: 8.096910013 
Odds Ratio: 0.413 
Reported genes: APOE
Context: missense_variant
Study title: The impact of low-frequency and rare variants on lipid levels. (R)
Initial sample size: up to 62,166 European ancestry individuals
Replication sample size:
Journal: Nat Genet (R)
Year published: May 11, 2015
Strength of evidence: Strong

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

Low density lipoprotein cholesterol measurement (P=3.00*10-53)
Risk Allele: T
Reported risk allele frequency: 12.00%
Impact: 2.5228787453 
Odds Ratio: 0.48 
Reported genes: APOE
Context: missense_variant
Study title: Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels. (R)
Initial sample size: 1,782 Filipino ancestry mothers
Replication sample size: 1,719 Filipino ancestry offsprings
Journal: J Lipid Res (R)
Year published: Sept. 10, 2013
Strength of evidence: Strong

Disease/Trait: Total Cholesterol Measurement

Total cholesterol measurement (P=2.00*10-30)
Risk Allele: T
Reported risk allele frequency: 12.00%
Impact: 9.6989700043 
Odds Ratio: 0.09 
Reported genes: APOE
Context: missense_variant
Study title: Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels. (R)
Initial sample size: 1,782 Filipino ancestry mothers
Replication sample size: 1,719 Filipino ancestry offsprings
Journal: J Lipid Res (R)
Year published: Sept. 10, 2013
Strength of evidence: Strong

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

Low density lipoprotein cholesterol measurement (P=2.00*10-9)
Risk Allele: None
Reported risk allele frequency: 10.00%
Impact: 8.6989700043 
Odds Ratio: 2.3 
Reported genes: APOE
Context: missense_variant
Study title: High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. (R)
Initial sample size: 1,249 African American individuals
Replication sample size:
Journal: Clin Transl Sci (R)
Year published: Aug. 23, 2012
Strength of evidence: Strong

Disease/Trait: Response To Statin

Response to statin (P=2.00*10-47)
Risk Allele: None
Reported risk allele frequency: None
Impact: 6.6989700043 
Odds Ratio: 6.2 
Reported genes: APOE
Context: missense_variant
Study title: Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (R)
Initial sample size: 6,989 European ancestry individuals
Replication sample size:
Journal: Circ Cardiovasc Genet (R)
Year published: Feb. 13, 2012
Strength of evidence: Strong

Disease/Trait: Lipid Measurement

Lipid measurement (P=3.00*10-58)
Risk Allele: None
Reported risk allele frequency: None
Impact: 7.5228787453 
Odds Ratio: 0.75 
Reported genes: APOE
Context: missense_variant
Study title: Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (R)
Initial sample size: 8,330 European ancestry individuals
Replication sample size:
Journal: Nat Genet (R)
Year published: Jan. 29, 2012
Strength of evidence: Strong