The "A" (major) allele is associated with:

  • AA = Increased VDR levels in stimulated immune cells.
  • AA = 31% lower risk of Parkinson's (p=0.04) (R).
  • AA = protection against Multiple Sclerosis in HLA-DRB1*15-positive individuals (R).
  • AA = Increased risk of kidney stones in Asians (R).
  • AA = calcium consumption was associated with decreased breast cancer rates in women (R). 
  • A = possible increased muscle strength in school children (R).
  • A = reduced risk of gum disease.

The "G" (minor) allele is associated with:

  • GG = Increased risk of gum disease.
  • G = decreased VDR levels in stimulated immune cells.
  • G = higher risk of Parkinson's (p=0.04) (R).
  • G = less protection against Multiple Sclerosis in HLA-DRB1*15-positive individuals (R).
  • G = weak evidence for an association w/ Multiple Sclerosis (R).
  • G = decreased risk of kidney stones (Asians) (R).
  • G = calcium consumption was associated with increased breast cancer rates in women (R). 
  • G = possible decreased muscle strength in school children (R).

rs731236

Parent Gene: VDR

Importance: 5
Less common allele: G = 28%
More common allele: A = 72%
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