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Mechanism:

  • C= Increased circulating Insulin-like Growth Factor (IGF) levels in the bloodstream [R, R2].

The "C" allele is associated with:

  • Higher body fat (Body mass index) in CC individuals, based on a study of Finnish male subjects [R].

  • Stronger muscular performance in CC individuals, based on a study of Finnish male subjects [R]. Muscular performance was assessed by measuring force output of rapid dual leg extensions.

  • Modestly higher % breast density with each C allele [R].  Higher breast density has been linked to higher risk of breast cancer [R].

The "T" allele is associated with:

  • Lower Body fat (Body mass index) compared to CC individuals, based on a study of Finnish male subjects  [R].

Haplotypes:

  • C/T at Rs6220/Rs7136446: Poorer Prostate cancer survival among patients with bone metastasis and with the both the T allele at SNP Rs7136446  and the C allele at  separate SNP Rs6220.

rs7136446

Parent Gene: IGF1
Importance: 3
Minor Allele: C = 28%
Major Allele: T = 72%
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