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The G (major) allele is associated with:

  • GG= reduced BCMO1 activity by 48% (R).
  • Participants with a G allele had a higher average beta carotene level than participants with a T allele (R).

The G allele may affect health negatively by reducing the availability of vitamin A (retinol) but also positively by increasing the plasma concentration of powerful antioxidant molecules. A number of studies have shown that higher plasma concentrations of antioxidant carotenoids are associated in a protective manner against the development of chronic diseases and disability  (R).


Parent Gene: BCO1, PKD1L2

Importance: 4
Minor Allele: T = 48%
Major Allele: G = 52%
My Genotype: Log In
Risk Allele: G