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Mechanism:

This SNP changes an amino acid in the nerve growth factor gene and therefore affects its function (G=Ala, A=Val). Nerve growth factor (NGF) plays a role in the functioning of the basal forebrain cholinergic neurones, which are involved in attentional systems.

The Minor "A" allele is associated with:

  • Increased susceptibility for anxiety by association with low vagal activity [R].
  • 1.47X increased risk of Alzheimer's (R).

The Major "G" allele is associated with:

  • In females, GG had higher levels of anxiety than AG or AA (R).
  • In males, GG had lower levels of anxiety than AG or AA (R).
  • In men, GG had a higher heart rate variability (high-frequency power and RMSSD) [R].
  • In women, GG had a nonsignificantly lower heart rate variability [R].
  • The G allele was significantly more common in people with ADHD (P=.05) (R).

rs6330

Parent Gene: NGF
Importance: 4
Minor Allele: A = 25%
Major Allele: G = 75%
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