Mechanism

  • The T allele is associated with abnormal packaging of the precursor of BDNF and decreased mature BDNF production in cells [R, R].

The T (minor) allele is associated with:

  • Lower BMI compared to the two other genotypes (TT) [R].

  • Lower systolic blood pressure [R].

  • Lower susceptibility to degenerative neurological disorders like Parkinsons, Huntingtons, Lupus, MS [R, R2].

  • Protection against depression when subjected to repeated defeat [R].

  • Lower incidence of decreased sexual desire (OR = 0.32, p = 0.01) as compared to the CC [R].

  • Preserved gray matter volume in MS [R].

  • Decreased hippocampal volume in some cases but not all [R].

  • More anxiety (TT) [R].

  • Introversion, depression resistant, impaired motor skills learning (TT) [R].

  • Introversion [R, R2]: the T allele is prevalent amongst Asians, which might explain increased introversion amongst Asians. [R].

  • Impaired learning and memory [R].

  • Worsened motor skills and increased likelihood of getting into a car accident [R].

  • Lengthened recovery time for stroke victims [R].

  • Increased likelihood of binge eating after dietary restriction [R].

  • Reduced overall performance in the verbal learning memory test, although not statistically significant [R].

  • Significantly lower N-acetyl-aspartate and Glutamate metabolic ratios compared with CC (TT). The difference between CT and CC was negligible. BDNF may exert its observed effects on NAA via its influence on the glutamate system [R].

  • A 33% increased risk of developing eating disorders, while also having a 21% protective effect in substance-related disorders (CT and TT). TT showed a 19% increased risk of schizophrenia compared to AG [R].

  • Poorer executive functioning in OCD [R].

  • Higher Alzheimer’s risk in non-APOE4 carriers [R].

  • Increased risk of suicidal behavior in depressed patients who had CT or TT.

  • Higher risk of alcohol-related depression [R].

  • Increased bipolar risk, although T responds better to treatment [R].

  • Recollection of a lower percentage of positive words in childhood [R].

  • Non-significant: Meta-analysis 6% increased the risk for depression TT vs CC. 3% decreased risk comparing CT with CC genotypes [R].

  • Sensitivity to Childhood adversity. The T allele has less gray matter compared to CCs with childhood adversity.

  • Higher heart disease-related depression [R].

  • Significantly reduced HPA axis/stress response to psychosocial stressors compared with individuals with the CC genotype [R].

  • Significantly lower N-acetyl-aspartate and Glutamate metabolic ratios compared with CC (TT). BDNF may exert its observed effects on NAA via its influence on the glutamate system [R].

  • Increased exercise participation due to positive attitiudes, increased motivation,and a reduced desire to stop once exercising [R, R].

The C (major) allele is associated with:

  • 20 minutes more slow-wave sleep (stage ¾) and increased sleep intensity compared to CT (CC) [R].

  • Double the EEG alpha waves (9.75-11.75 Hz) compared to the CT genotype subjects (both in a rested and also a sleep-deprived state)  (CC) [R].

  • The slowest wave activity in the first slow wave cycle. Slow wave activity tended to decline more in CC compared to CT in subsequent cycles (CC) [R].

  • Better response accuracy than T on a verbal 2-back working memory task (CC) [R].

  • 19.3 of BDNF in CC compared to 17.0 of BDNF in TT and CT, not too significant of a difference [R]. Other factors of BDNF are also altered.

  • Higher performance in digital working memory and spatial localization than TT in Chinese (CC) [R].

  • Higher mean intelligence [R].

  • Better response to repetitive transcranial magnetic stimulation, with drug-resistant depression (CC) [R].

  • Seeking positive emotions (e.g., happy faces) and having a stronger reaction to negative emotions (e.g., angry, fearful, and sad faces) compared to CT (CC) [R].

  • Reduced stress-induced anxiety-like behavior (CC) compared to TT [R]. 

  • Higher scores on trait-anxiety and neuroticism (not significant) compare to CT or TT (CC) [R], although other studies have not found an association with Neuroticism [R].

  • Higher risk of depression (1.7X) [R].

  • Higher risk for allergies (CC). Increased levels of BDNF in blood, lung fluid, and nose fluid positively correlate with disease activity and severity in patients with allergic rhinitis [AR], asthma and atopic eczema [R].

  • ADHD while CT is associated with both ADHD and intellectual disability [R].

  • Twice the risk of being an overweight male compared to those with a T allele (CC). Women with CC were 50% less likely to be overweight than people with a T allele were [R].

  • The lower weight of men who consumed more PUFA (more than 8.76% of calories) (CC) [R]. 

  • The lower weight of women who consumed more PUFA (more than 8.76% of calories), although not statistically significant (CC) [R].

  • A greater increase in salivary cortisol than CT in response to stress in men (CC) [R].

  • Depression in individuals with higher levels of cortisol in CC but not CT [R].  

rs6265

Parent Gene: BDNF

Importance: 5
Less common allele: T = 20%
More common allele: C = 80%
My Genotype: Log In
Risk Allele: T, T, T, G, G, C

Disease/Trait: Hip Circumference

The T allele of rs6265 is reported to be associated with Hip Circumference (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Hip circumference (EA, men).

Disease/Trait: Hip Circumference

The T allele of rs6265 is reported to be associated with Hip Circumference (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Hip circumference (EA,women).

Disease/Trait: Hip Circumference

The T allele of rs6265 is reported to be associated with Hip Circumference (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Hip circumference (EA).

Disease/Trait: Body Mass Index

The G allele of rs6265 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index.

Disease/Trait: Body Weight

The G allele of rs6265 is reported to be associated with Body Weight (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Weight.

Disease/Trait: Smoking Behavior

The C allele of rs6265 is reported to be associated with Smoking Behavior (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Smoking behavior (smoking initiation).