Mechanism:

  • Higher levels of BDNF than A (increased transcription) (GG) [R].
  • Increased BDNF (G)
  • Lower BDNF production through altered mRNA folding and splicing (A) [R,R2].

The "A" (minor) allele is associated with:

  • higher risk for multiple sclerosis (in the Polish population) [R].
  • increased risk of schizophrenia (in east Asian subjects)[R].
  • higher risk of hallucinations in Alzheimer's patients [R].

The "G" (major) allele is associated with:

  • higher risk of anorexia nervosa and bulimia [R,R2].
  • increased risk of ADHD and learning disabilities in children [R].
  • higher risk for asthma (in Chinese Han children) [R].

This SNP is associated with (unknown which alleles):

  • Alcohol and substance abuse [R].

rs56164415

Parent Gene: BDNF

Importance: 3
Less common allele: A = 10%
More common allele: G = 90%
My Genotype: Log In