Mechanism:

GG promotes the efficient functioning of the oxytocin system and enhances the effects of oxytocin supplementation. (R) The gene frequency varies by race: ~61% of Africans have it (in Africa), ~41% of Europeans (~30% of Finns)and ~10% of Asians. (R)

The Minor "A" allele is associated with:

  • AA and AG individuals were judged to be less pro-social and displayed fewer nonverbal cues compared to GG people. The study suggested that the association between and prosociality was stronger for men, but also true for women. (R)
  • GG are better at accurately reading the emotions of others by observing their faces. (R) compared to AA or AG. GG was more mellow and more attuned to other people than were the AA or AG.(R)
  • In response to an interview, GG or AG had significantly lower cortisol responses to stress when they had social support. There were no differences in cortisol levels in subjects with the AA genotype receiving or not receiving social support. The AA genotype tended to have higher levels of cortisol throughout the session than G carriers (no differences between the genotypes were observed at baseline). (R)
  • GG was less empathetic to pain experienced by racial 'out group' vs racial 'in group' members (Asians vs Whites). However, AA experienced more pleasure from pain to racial out-groups. (R)
  • So GG cares less about other races or who they view as 'other' (including competitions), but AA experiences more schadenfreude, which is pleasure at out-group pain or downfall.(R)

The Major "G" allele is associated with:

  • GG have a more positive 'affect' or disposition (R). AA and AG individuals were judged to be less pro-social and displayed fewer nonverbal cues, head nods and smiles compared to GG people. The study suggested that the association between and prosociality was stronger for men, but also true for women (R).
  • GG are more optimistic (R)
  • GG are more empathetic (R)
  • GG handle stress better (R)
  • GG are better at accurately reading the emotions of others by observing their faces (R) compared to AA or AG.
  • GG are less likely to startle when blasted by a loud noise, or to become stressed at the prospect of such a noise (R)
  • GG was more mellow and more attuned to other people than were the AA or AG (R)
  • GG have a higher Verbal IQ (R)
  • GG feel less lonely (R)
  • GG was less likely to seek support from their peers (R)
  • GG employ more sensitive parenting techniques (R)
  • GG have lower rates of autism (R)
  • GG have less difficulty hearing and understanding in noisy environments (R)
  • In response to an interview, GG or AG had significantly lower cortisol responses to stress when they had social support. There were no differences in cortisol levels in subjects with the AA genotype receiving or not receiving social support. The AA genotype tended to have higher levels of cortisol throughout the session than G carriers (no differences between the genotypes were observed at baseline) (R)
  • GG have more gray matter volume in the hypothalamus and greater hypothalamus volume and more activation in the amygdala (R)
  • GG are less predisposed to major depression (R)
  • GG take social rejection worse than others. GG had higher blood pressure and cortisol levels the following rejection, effects not apparent among A carriers. (R)
  • GG was less empathetic to pain experienced by racial 'out group' vs racial 'in group' members (Asians vs Whites). However, AA experienced more pleasure from pain to racial out-groups. (R)
  • So GG cares less about other races or who they view as 'other' (including competitions), but AA experiences more schadenfreude, which is pleasure at out-group pain or downfall.(R)

rs53576

Parent Gene: OXTR

Importance: 5
Less common allele: A = 39%
More common allele: G = 61%
My Genotype: Log In