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Mechanism:

  • Normal levels of Insulin-like Growth Factor Receptor 1 (IGF1R) (GG)
  • Normal levels of IGF1R (G)
  • Decreased levels of IGF1R  (A) [R].
  • IGF1R mediates the effects of Insulin-like growth factor 1 (IGF1). IGF1 is important in growth and development in fetuses and infants [R].

The Minor "A" allele is associated with:

  • Smaller birth weight and birth size [R].
  • Fetal growth failure [R]. This may cause future problems such as hypertension, cardiovascular disease, and diabetes [R].

The Major "G" allele is associated with:

  • Decrease risk of Fetal Growth failure [R].

Other:

  • IGF1R is associated with the risk of developing cancer [R]. Rs4966035 has been found to be associated with the risk of developing breast cancer [R]. More research needs to be done to confirm this.

rs4966035

Parent Gene: IGF1R
Importance: 2
Minor Allele: A = 44%
Major Allele: G = 56%
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