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The Minor "G" allele is associated with:

  • Women homozygous for the allele had higher B(12) levels in the blood (R). This is thought to be caused by increased B(12) absorption.

The Major "A" allele is associated with:

  • The A allele is more likely to contract H pylori (R) The H-antigen synthesized by FUT2 allows H. pylori to take hold in the gut (R).
  • Absorption of B12 requires the secretion of intrinsic factor (IF) from the gastric cells, binding of IF to vitamin B12 and a functional gastrointestinal absorption system.
  • Possible malabsorption of vitamin B12 (R).

rs492602

Parent Gene: FUT2

Importance: 5
Less common allele: G = 32%
More common allele: A = 68%
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Risk Allele: G, C, G, G, A