The Minor "G" allele is associated with:
- Women homozygous for the G allele had higher B(12) levels in the blood (R). This is thought to be caused by increased B(12) absorption.
The Major "A" allele is associated with:
- The A allele is more likely to contract H pylori (R) The H-antigen synthesized by FUT2 allows H. pylori to take hold in the gut (R).
- Absorption of B12 requires the secretion of intrinsic factor (IF) from the gastric cells, binding of IF to vitamin B12 and a functional gastrointestinal absorption system.
- Possible malabsorption of vitamin B12 (R).