Mechanism:

92% similar to main SNP: rs7903146.

The T (minor) allele is associated with:

  • Each T= lower insulin levels because GLP-1 and GIP don't cause as much insulin secretion.
  • Each T= lower glucagon levels.
  • Increased risk of diabetes.

rs4506565

Parent Gene: TCF7L2

Importance: 3
Less common allele: None = None
More common allele: A = None
My Genotype: Log In
Risk Allele: T, T

Disease/Trait: Mortality

rs4506565 is associated with Mortality (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Glucose Measurement

rs4506565 is associated with Glucose Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Diabetes Mellitus

rs4506565 is associated with Diabetes Mellitus (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Heart Failure

rs4506565 is associated with Heart Failure (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Systolic Blood Pressure

rs4506565 is associated with Systolic Blood Pressure (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Triglyceride Measurement

rs4506565 is associated with Triglyceride Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Diastolic Blood Pressure

rs4506565 is associated with Diastolic Blood Pressure (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Cancer

rs4506565 is associated with Cancer . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

rs4506565 is associated with High Density Lipoprotein Cholesterol Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Atrial Fibrillation

rs4506565 is associated with Atrial Fibrillation (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Body Mass Index

rs4506565 is associated with Body Mass Index (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Coronary Heart Disease

rs4506565 is associated with Coronary Heart Disease (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Ventricular Rate Measurement

rs4506565 is associated with Ventricular Rate Measurement . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Stroke

rs4506565 is associated with Stroke (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Hematocrit

rs4506565 is associated with Hematocrit (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Total Cholesterol Measurement

rs4506565 is associated with Total Cholesterol Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Mortality

rs4506565 is associated with Mortality (R) . It is reported to association with Age-related diseases and mortality. No specific risk allele was identified in the study.

Disease/Trait: Atrial Fibrillation

rs4506565 is associated with Atrial Fibrillation (R) . It is reported to association with Age-related diseases and mortality. No specific risk allele was identified in the study.

Disease/Trait: Coronary Heart Disease

rs4506565 is associated with Coronary Heart Disease (R) . It is reported to association with Age-related diseases and mortality. No specific risk allele was identified in the study.

Disease/Trait: Stroke

rs4506565 is associated with Stroke (R) . It is reported to association with Age-related diseases and mortality. No specific risk allele was identified in the study.

Disease/Trait: Diabetes Mellitus

rs4506565 is associated with Diabetes Mellitus (R) . It is reported to association with Age-related diseases and mortality. No specific risk allele was identified in the study.

Disease/Trait: Heart Failure

rs4506565 is associated with Heart Failure (R) . It is reported to association with Age-related diseases and mortality. No specific risk allele was identified in the study.

Disease/Trait: Cancer

rs4506565 is associated with Cancer . It is reported to association with Age-related diseases and mortality. No specific risk allele was identified in the study.

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

rs4506565 is associated with High Density Lipoprotein Cholesterol Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Body Mass Index

rs4506565 is associated with Body Mass Index (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Glucose Measurement

rs4506565 is associated with Glucose Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Ventricular Rate Measurement

rs4506565 is associated with Ventricular Rate Measurement . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Hematocrit

rs4506565 is associated with Hematocrit (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Systolic Blood Pressure

rs4506565 is associated with Systolic Blood Pressure (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Triglyceride Measurement

rs4506565 is associated with Triglyceride Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Diastolic Blood Pressure

rs4506565 is associated with Diastolic Blood Pressure (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Total Cholesterol Measurement

rs4506565 is associated with Total Cholesterol Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Fasting Blood Glucose Measurement

The T allele of rs4506565 is reported to be associated with Fasting Blood Glucose Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Fasting glucose-related traits (FPG).

Disease/Trait: Type Ii Diabetes Mellitus

The T allele of rs4506565 is reported to be associated with Type Ii Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Type 2 diabetes.