The C (minor) allele is associated with:

  • 1.7x increased risk of gallstone disease in subjects with biliary tract conditions (R).
  • 1.8x increased risk of gallbladder cancer in subjects with biliary tract conditions (R).
  • 3.7x increased risk of bile duct cancer in subjects with biliary tract conditions (R).
  • 4x increased risk of ampullary cancer (intestinal) (R).

Incomplete

rs440446

Parent Gene: APOE

Importance: 3
Less common allele: C = 37%
More common allele: G = 63%
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