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The Minor "A" allele is associated with:

  • Significant increase in the risk of developing an autoimmune disease with each A allele. 
  • D3 is protective

rs3135388

Parent Gene: HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5
Importance: 5
Minor Allele: A = 4%
Major Allele: G = 96%
My Genotype: Log In
Risk Allele: A, A, A

Disease/Trait: Oligoclonal Band Measurement

The A allele of rs3135388 is reported to be associated with Oligoclonal Band Measurement(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Oligoclonal band status in multiple sclerosis.

Reported risk allele frequency: 28.00%
Reported genes: HLA-DQA1 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 2.23
Risk Allele: A (P=4.00*10-15)
Context: upstream_gene_variant; downstream_gene_variant; upstream_gene_variant
Study title: Genetic variants are major determinants of CSF antibody levels in multiple sclerosis. (R)
Initial sample size: 2,232 European ancestry OCB positive individuals, 275 European ancestry OCB negative individuals, 439 OCB positive individuals, 80 OCB negative individuals
Replication sample size: 3,026 OCB positive individuals, 452 OCB negative individuals
Journal: Brain (R)
Year published: Jan. 22, 2015
Strength of evidence: Strong

Disease/Trait: Multiple Sclerosis

The A allele of rs3135388 is reported to be associated with Multiple Sclerosis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Oligoclonal band status in multiple sclerosis.

Reported risk allele frequency: 28.00%
Reported genes: HLA-DQA1 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 2.23
Risk Allele: A (P=4.00*10-15)
Context: upstream_gene_variant; downstream_gene_variant; upstream_gene_variant
Study title: Genetic variants are major determinants of CSF antibody levels in multiple sclerosis. (R)
Initial sample size: 2,232 European ancestry OCB positive individuals, 275 European ancestry OCB negative individuals, 439 OCB positive individuals, 80 OCB negative individuals
Replication sample size: 3,026 OCB positive individuals, 452 OCB negative individuals
Journal: Brain (R)
Year published: Jan. 22, 2015
Strength of evidence: Strong

Disease/Trait: Multiple Sclerosis

The A allele of rs3135388 is reported to be associated with Multiple Sclerosis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Multiple sclerosis.

Reported risk allele frequency: 23.00%
Reported genes: HLA-DQA1 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 1.99
Risk Allele: A (P=9.00*10-81)
Context: downstream_gene_variant
Study title: Risk alleles for multiple sclerosis identified by a genomewide study. (R)
Initial sample size: 931 European ancestry trios, 2,431 European ancestry controls
Replication sample size: 609 European ancestry trios, 2,322 European ancestry cases, 2,987 European ancestry controls
Journal: N Engl J Med (R)
Year published: July 29, 2007
Strength of evidence: Strong