rs2976392 a SNP of the PSCA gene. It is strongly associated with the susceptibility to gastric cancer (OR = 1.62) [RR1R2R3R4R5].

''GA/AA'' genotypes together with alcohol drinking were associated with the development of intestinal-type gastric cancer (p = 0.009) [RR1].

Individuals with at least one copy of the ''A'' allele (GA or AA genotype) had an increased risk for noncardia gastric carcinoma (NCGC) compared with those without this allele (OR = 1.20) [RR1].

 

rs2976392

Parent Gene: PSCA

Importance: 2
Less common allele: A = 40%
More common allele: G = 60%
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