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Mechanism:

  • Increased Insulin-like Growth Hormone (IGF1) (GA) [R].

  • Increased IGF-1 (but not statistically significant) (GG) [R].

The Minor "A" allele is associated with:

  • Lower breast density in women with the AA genotype [R]. Lower breast density means a lower ratio of breast tissue to fatty tissue, measured by a mammogram. Lower breast density has been associated with reduced risk of breast cancer[R].

  • Increased risk of the eye disorder Myopia. According to one study, individuals with any type of Myopia were more likely to carry the A allele than those without, though this result was not statistically vetted [R].

  • Better tumor response rates to treatment with the drug Cetuximab, in patients with colon cancer. In one study, patients with the AA genotype were much more likely to see complete or partial tumor disappearance, than those with either the AG or GG genotype [R].

  • Higher “progression-free survival” in colon cancer patients treated with Cetuximab [R]. Patients with the AA genotype tended to survive longer without any progression of the disease.

  • Poor outcomes in women with HER-2 positive breast cancer. In a study of 161 caucasian women, patients with an A allele were more likely to relapse [R].

  • Increased risk of having advanced-stage prostate cancer, based on a study of 320 Taiwanese cancer patients who had received a prostatectomy [R].

The Major "G" allele is associated with:

  • Resistance to treatment with the drug Cetuximab in colon cancer patients. In one study, none of the patients with the AG genotype experienced any tumor response to the drug [R].

rs2946834

Parent Gene: IGF1
Importance: 3
Minor Allele: A = 40%
Major Allele: G = 60%
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