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Mechanism:

  • This SNP (C to G, Ala to Gly) is in the coding region of the insulin-like growth factor binding protein (IGFBP3), something that attaches to a growth factor in the blood, and prevents it from acting. The effect of this is to put less of the protein in the blood, so there is less to attach to the growth factor. This makes the growth factor have more of an effect so cells grow faster (R).
  • Lower IGF protein levels (C) (R)
  • Increased levels of IGFBP3 (C)(R)
  • Normal levels of IGFBP3 (G)

The Minor "C" allele is associated with:

  • Increased Survival in gastric cancer patients (R)
  • Decreased risk of colorectal cancer (R)
  • Decreased risk of ovarian cancer (R)

The Major "G allele is associated with:

  • Increased prostrate cancer risk (among Whites) (R)
  • Increased colorectal cancer risk (R)
  • Increased risk of proliferative benign breast disease (R)
  • Increased size of size of uterine leiomyomata (among Blacks) (R)

rs2854746

Parent Gene: IGFBP3
Importance: 3
Minor Allele: C = 42%
Major Allele: G = 57%
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