The Minor "A" allele is associated with:

  • Higher levels of enzyme and had lower Estradiol (AA)
  • Higher inactive metabolites (AA)
  • Each A lowers risk for lung cancer in subjects who never smoked (50%), but increases risk in people who have smoked. This might be because AA will break down carcinogens fast, but if you have a higher toxin load, it will cause too high of a toxin buildup.

rs2606345

Parent Gene: CYP1A1

Importance: 3
Less common allele: A = 28%
More common allele: C = 72%
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