- Normal levels of IGFBP3 in the body (G)
- Decreased amounts of IGFBP3 in the body (C) [R][R].
- IGFBP3 binds insulin growth factors 1 and 2 (IGF-1, IGF-2) and acts as a the main carrier of both factors through the bloodstream [R].
The Minor "C" allele is associated with:
- Breast cancer in high genetic risk cancer patients [R].
- Increased fibroids (abnormal growths) in the female uterus [R]. These growths are often non-cancerous but can cause abdominal pain and heavy periods in those that have them [R].
- Increased size of fibroids in the female uterus [R].
- Because they are abnormal growth, these abnormal growths could result in uterine cancer.
- Low levels of IGFBP3 in the body may result in lower risk of developing other cancers [R].
- Possible increased survival rate in subjects with cancer due to low IGFBP3 levels [R].
The Major "G" allele is associated with: