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Mechanism:

  • Normal levels of IGFBP3 in the body (G)
  • Decreased amounts of IGFBP3 in the body (C) [R][R].
  • IGFBP3 binds insulin growth factors 1 and 2 (IGF-1, IGF-2) and acts as a the main carrier of both factors through the bloodstream [R].

The Minor "C" allele is associated with:

  • Breast cancer in high genetic risk cancer patients [R].
  • Increased fibroids (abnormal growths) in the female uterus [R]. These growths are often non-cancerous but can cause abdominal pain and heavy periods in those that have them [R].
  • Increased size of fibroids in the female uterus [R].
  • Because they are abnormal growth, these abnormal growths could result in uterine cancer.
  • Low levels of IGFBP3 in the body may result in lower risk of developing other cancers [R].
  • Possible increased survival rate in subjects with cancer due to low IGFBP3 levels [R].

The Major "G" allele is associated with:

  • Lower risk of Breast cancer [R].
  • Decreased fibroids within the female uterus [R].
  • Lower risk of uterine cancer.
  • High IGFBP3, which may cause an increase in the risk of developing cancers [R].
  • Possible decreased survival rate in subjects with cancer due to high IGFBP3 levels [R].

rs2471551

Parent Gene: IGFBP3
Importance: 3
Minor Allele: C = 18%
Major Allele: G = 82%
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