- IGFBP3 binds insulin growth factors 1 and 2 (IGF-1, IGF-2) and acts as a the main carrier of both factors through the bloodstream [R].
- Normal levels of IGFBP3 in the body (T)
- Decreased amounts of IGFBP3 in the body (C) [R].
The Minor "C" allele is associated with:
- Avascular necrosis of femoral head (ANFH) [R]. ANFH occurs when the femoral head is cut off from the bloodstream [R]. ANFH results in bone collapse [R].
- Other avascular necrosis events due to low IGFBP3 levels.
- Decreased risk of developing endometrial cancer [R].
- Increased mammographic breast density [R]. This may increase the risk of developing breast cancer and also makes it harder to read a mammogram [R].
- May play a role in breast carcinogenesis [R].
The Major "T" allele is associated with: