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The Minor "T" allele is associated with:

  • 2.72X higher risk for Type 1 Diabetes (R).
  • Lower risk for Ulcerative Colitis (.88X the normal risk). 
  • 9.5X higher risk of Type 1 Diabetes (TT). 
  • 0.58X risk of Ulcerative Colitis (TT). 

rs2395185

Parent Gene: HLA-DRA, HLA-DRB1, HLA-DRB5
Importance: 5
Minor Allele: T = 29%
Major Allele: G = 71%
My Genotype: Log In
Risk Allele: G, T, G

Disease/Trait: Antinuclear Antibody Measurement

rs2395185 is associated with Antinuclear Antibody Measurement(R). It is reported to have a 0.25 unit increase on Antinuclear antibody levels. No specific risk allele was identified in the study.

Reported risk allele frequency: None
Reported genes: HLA-DRA , HLA-DRB1 , HLA-DRB5
Beta coefficient: 0.25 unit increase
Risk Allele: None (P=1.00*10-11)
Context: intron_variant
Study title: An association between anti-nuclear antibody and HLA class II locus and heterogeneous characteristics of staining patterns: The Nagahama Study. (R)
Initial sample size: 3,185 Japanese ancestry individuals
Replication sample size: 3,963 Japanese ancestry individuals
Journal: Arthritis Rheumatol (R)
Year published: Sept. 3, 2014
Strength of evidence: Strong

Disease/Trait: Ulcerative Colitis

The G allele of rs2395185 is reported to be associated with Ulcerative Colitis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Ulcerative colitis.

Reported risk allele frequency: None
Reported genes: HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 1.49
Risk Allele: G (P=9.00*10-23)
Context: intron_variant
Study title: Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (R)
Initial sample size: 2,693 European ancestry cases, 6,791 European ancestry controls
Replication sample size: 2,009 European ancestry cases, 1,580 European ancestry controls
Journal: Nat Genet (R)
Year published: March 14, 2010
Strength of evidence: Strong

Disease/Trait: Lung Carcinoma

The T allele of rs2395185 is reported to be associated with Lung Carcinoma(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Lung cancer.

Reported risk allele frequency: 35.00%
Reported genes: HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 1.17
Risk Allele: T (P=1.00*10-8)
Context: intron_variant
Study title: Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. (R)
Initial sample size: 5,510 East Asian ancestry cases, 4,544 East Asian ancestry controls
Replication sample size: 1,099 East Asian ancestry cases, 2,913 East Asian ancestry controls
Journal: Nat Genet (R)
Year published: Nov. 11, 2012
Strength of evidence: Strong

Disease/Trait: Ulcerative Colitis

The G allele of rs2395185 is reported to be associated with Ulcerative Colitis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Ulcerative colitis.

Reported risk allele frequency: 61.00%
Reported genes: HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 1.92
Risk Allele: G (P=5.00*10-22)
Context: intron_variant
Study title: A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (R)
Initial sample size: 376 Japanese ancestry cases, 934 Japanese ancestry controls
Replication sample size: 376 Japanese ancestry cases, 1,097 Japanese ancestry controls
Journal: Nat Genet (R)
Year published: Nov. 15, 2009
Strength of evidence: Strong

Disease/Trait: Hodgkins Lymphoma

rs2395185 is associated with Hodgkins Lymphoma(R). It is reported to increased association with Hodgkin's lymphoma (Total cHL). No specific risk allele was identified in the study.

Reported risk allele frequency: None
Reported genes: HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 1.82
Risk Allele: None (P=4.00*10-31)
Context: intron_variant
Study title: Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. (R)
Initial sample size: 1,200 European ancestry cases, 6,417 European ancestry controls
Replication sample size: 563 European ancestry cases, 613 European ancestry controls
Journal: J Natl Cancer Inst (R)
Year published: Jan. 27, 2012
Strength of evidence: Strong

Disease/Trait: Ulcerative Colitis

rs2395185 is associated with Ulcerative Colitis(R). It is reported to increased association with Ulcerative colitis. No specific risk allele was identified in the study.

Reported risk allele frequency: 67.00%
Reported genes: HLA-DRA , HLA-DRB1 , HLA-DRB5
Odds ratio: 1.52
Risk Allele: None (P=1.00*10-16)
Context: intron_variant
Study title: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (R)
Initial sample size: 1,022 European ancestry cases, 2,503 European ancestry controls
Replication sample size: 1,387 European ancestry cases, 1,115 European ancestry controls
Journal: Nat Genet (R)
Year published: Jan. 4, 2009
Strength of evidence: Strong