Mechanism:

  • CYP24A1 breaks down the active form of vitamin D (Calcitriol).
  • Although the SNP does not change the amino acid sequence, it could alter protein levels of CYP24A1.
  • Mutations in human CYP24A1 have been shown to modulate the level of this enzyme in selective tissue.
  • This SNP could have a functional impact on vitamin D response element binding (R).

The Major "G" allele is associated with:

  • A meta-analysis found that subjects with GG had reduced the risk of androgen-related prostate cancer (R).
  • Subjects with a G had decreased the risk of oral cancer (R).
  • Subjects with a G had a lower risk of oral lichen planus (R).

rs2296241

Parent Gene: CYP24A1

Importance: 3
Less common allele: A = 46%
More common allele: G = 54%
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