- Higher activity of FAAH protein (G) (R).
The G (major) allele is associated with:
- Presence of the G allele was linked with an increase of recollections of the traumatic event(R). G subjects showed more intense recollections of traumatic events and of negative childhood experiences (R).
- Increased risk of developing PTSD compared to AA subjects (R). In one study, rs2295633 was the only FAAH SNP to reveal a significant difference in PTSD prevalence (G)
- Negative early experiences increased PTSD risk only in those subjects presenting at least one G(R).
- The G allele could serve as a possible marker for increased PTSD risk in subjects exposed to brain injury and combat experiences (R).
- Higher arousal and lower fatigue levels after amphetamine ingestion (R). Increased arousal has been linked with reduced FAAH activity in animal models, thus suggesting possible higher FAAH activity in G allele carriers (GG) (R).