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[PMID 19653082] Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn's Disease in the Japanese Population


[PMID 19776189] Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults


[PMID 22205606] JAK2 and STAT3 polymorphisms in a Han Chinese Population with Behcet's disease

[PMID 15935090] Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma.


[PMID 17636079] Common STAT3 variants are not associated with obesity or insulin resistance in female twins.


[PMID 18451776] Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults.


[PMID 18520591] Sequence variants in host cell factor C1 are associated with Meniere's disease.


[PMID 18789715] Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease.


[PMID 20159113] Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.


[PMID 21068102] Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese.


[PMID 21310444] Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 (STAT3).


[PMID 22095036] Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.


[PMID 23127549] Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease


[PMID 23611997] JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population


[PMID 24081513] Association of single-nucleotide polymorphisms in the STAT3 gene with autoimmune thyroid disease in Chinese individuals


[PMID 24781989] Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population


[PMID 24864251] rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population


[PMID 26745093] Single Nucleotide Polymorphisms in STAT3 and STAT4 and Risk of Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B.

rs2293152

Parent Gene: STAT3
Importance: 3
Minor Allele: G = 35%
Major Allele: C = 65%
My Genotype: Log In
Risk Allele: C

Disease/Trait: Multiple Sclerosis

The C allele of rs2293152 is reported to be associated with Multiple Sclerosis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Multiple sclerosis.

Reported risk allele frequency: 62.00%
Reported genes: STAT3
Odds ratio: 1.22
Risk Allele: C (P=4.00*10-8)
Context: intron_variant
Study title: Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (R)
Initial sample size: 5,545 European ancestry cases, 12,153 European ancestry controls
Replication sample size:
Journal: Ann Neurol (R)
Year published: Dec. 1, 2011
Strength of evidence: Strong