• The SNP is within the Acetyl-coenzyme A carboxylase beta (ACACB) gene (R).
  • The gene is important in fatty acid synthesis and preventing fatty acid oxidation (R).

The A (minor) allele is associated with:

  • Increased risk of diabetic kidney disease in diabetics (R).
  • Increased BMI in most populations (but not Japanese)(R).
  • Increased liver triglyceride levels (R).

  • Increased risk of type II diabetes (R).

  • Increased risk of proteinuria, caused by proteins entering urine (R). This is indicative of kidney damage.

rs2268388

Parent Gene: ACACB

Importance: 3
Less common allele: A = 16%
More common allele: G = 84%
My Genotype: Log In