- The SNP is within the Acetyl-coenzyme A carboxylase beta (ACACB) gene (R).
- The gene is important in fatty acid synthesis and preventing fatty acid oxidation (R).
The A (minor) allele is associated with:
- Increased risk of diabetic kidney disease in diabetics (R).
- Increased BMI in most populations (but not Japanese)(R).
Increased liver triglyceride levels (R).
Increased risk of type II diabetes (R).
Increased risk of proteinuria, caused by proteins entering urine (R). This is indicative of kidney damage.