Mechanism:

  • Higher levels of IL-4 protein, which shows higher binding affinity to nuclear transcription factors (T).

The Minor "T" allele is associated with:

  • 0.6x decreased risk of having a myocardial infarction (heart attack) if younger than 50 (CT).
  • 0.33x decreased risk of having a myocardial infarction (heart attack) if younger than 50 (TT).

rs2243250

Parent Gene: IL4

Importance: 5
Less common allele: T = 47%
More common allele: C = 53%
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