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Mechanism:

  • Normal levels of IGFBP3 in the body (G).
  • Decreased amounts of IGFBP3 in the body (T) [R].
  • IGFBP3 binds insulin growth factors 1 and 2 (IGF-1, IGF-2) and acts as the main carrier of both factors through the bloodstream [R].

The Minor "T" allele is associated with:

  • Lower risk of benign breast disease (BBD) [R]. This disease increases the risk of breast cancer [R].
  • Muscle soreness after muscle exercise in men [R].
  • Increased response to recombinant human growth hormone [R].
  • Decreased risk of prostate cancer and other cancers due to lower IGFBP3 levels in the body [R] [R].

The Major "G" allele is associated with:

  • Decreased muscle soreness after muscle exercise in men [R].
  • Increased risk of prostate cancer and other forms of cancer due to higher IGFBP3 levels in the body [R] [R].
  • Higher risk of BBD and breast cancer [R].

rs2132570

Parent Gene: IGFBP3
Importance: 3
Minor Allele: T = 22%
Major Allele: G = 78%
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