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The T allele is associated with:

  • higher risk of Crohn disease with heterozygous have a 2x greater risk and homozygous (TT) giving a risk of 17x (R). 
  • lower risk of tuberculosis (R).


Parent Gene: NOD2

Importance: 1
Minor Allele: T = 1%
Major Allele: C = 99%
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Risk Allele: