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The T allele is associated with:

  • higher risk of Crohn disease with heterozygous have a 2x greater risk and homozygous (TT) giving a risk of 17x (R). 
  • lower risk of tuberculosis (R).

rs2066844

Parent Gene: NOD2
Importance: 1
Minor Allele: T = 1%
Major Allele: C = 99%
My Genotype: Log In
Risk Allele:

Disease/Trait: Inflammatory Bowel Disease

rs2066844 is associated with Inflammatory Bowel Disease(R). It is reported to association with Inflammatory bowel disease. No specific risk allele was identified in the study.

Reported risk allele frequency: None
Reported genes: NOD2
Risk Allele: None (P=1.00*10-38)
Context: missense_variant
Study title: Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. (R)
Initial sample size: 25,042 European and unknown ancestry cases, 34,915 European and unknown ancestry controls
Replication sample size:
Journal: Nat Genet (R)
Year published: Jan. 9, 2017
Strength of evidence: Strong

Disease/Trait: Crohn's Disease

rs2066844 is associated with Crohn'S Disease(R). It is reported to association with Crohn's disease. No specific risk allele was identified in the study.

Reported risk allele frequency: None
Reported genes: NOD2
Risk Allele: None (P=6.00*10-99)
Context: missense_variant
Study title: Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. (R)
Initial sample size: 12,194 European and unknown ancestry cases, 28,072 European and unknown ancestry controls
Replication sample size:
Journal: Nat Genet (R)
Year published: Jan. 9, 2017
Strength of evidence: Strong