rs1801157, also known as G801A, is a SNP in the chemokine (C-X-C motif) ligand 12 CXCL12 gene. rs1801157(A) was associated with protection against infection (OR=0.63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). [R] HIV-1/AIDS

A 2011 meta-analysis (comprising 5 studies totaling 1,058 cases) found that the rs1801157(A) allele was associated with higher risk for breast cancer, with an odds ratio of 1.44 (CI: 1.2 - 1.7; under a dominant model).[R]



Parent Gene: CXCL12

Importance: 1
Less common allele: None = None
More common allele: C = None
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