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Mechanism:

The A (minor) allele is associated with higher levels of TNF levels. This SNP has been linked to a wide variety of conditions.

The minor "A" allele is associated with:

  • Increased risk of Irritable Bowel Syndrome (IBS) (R) 41% of people with one A allele had IBS vs 26% of the people that didn't (R).
  • Increased risk of Asthma.
  • Increased risk of COPD.
  • Increased risk of Crohn's Disease.
  • Increased risk of Grave's Disease.
  • Increased risk of Heart disease.
  • Increased risk of Liver disease.
  • Increased risk of Lymphoma.
  • Increased risk of lupus (SLE)
  • Increased risk of Sarcoidosis.
  • 1.22X increased migraines (R).
  • higher blood insulin (R).
  • Decreased improvements in fitness following exercise [R]. High TNF levels could be preventing muscle regeneration.

rs1800629

Parent Gene: TNF

Importance: 4
Minor Allele: A = 9%
Major Allele: G = 91%
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