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The A (minor) allele is associated with:

  • AA= higher TGF-Œ≤1 levels because more TGF-Œ≤1 is produced, by preventing AP1 from binding to this region where in the C version it would normally downregulate production.
  • A= lower Bone Density

The G (major) allele is associated with:

  • GG= lower TGF-Œ≤1 levels, causing a higher risk for COPD.
  • AG=slightly higher TGF-Œ≤1 levels, causing slightly higher risk for COPD.

 

rs1800469

Parent Gene: B9D2, TGFB1

Importance: 4
Less common allele: A = 37%
More common allele: G = 63%
My Genotype: Log In
Risk Allele: A, G, G

Disease/Trait: Colorectal Cancer

The A allele of rs1800469 is reported to be associated with Colorectal Cancer (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Colorectal cancer Han Chinese.

Disease/Trait: Colorectal Cancer

The G allele of rs1800469 is reported to be associated with Colorectal Cancer (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Colorectal cancer.

Disease/Trait: Colorectal Cancer

The G allele of rs1800469 is reported to be associated with Colorectal Cancer (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Colorectal cancer (East Asian).