Mechanism:

  • The T (minor) allele= Increased DNA methylation of the FADS1 promoter, causing lower levels of FADS1 protein [R].

  • The G (major) allele= Normal levels of FADS1 protein [R].

The T (minor) allele is associated with:

  • Lower levels of arachidonic acid in the body [R]. Arachidonic acid is an Omega-6 polyunsaturated fatty acid.

  • Decreased risk of prostate cancer and better prognosis of disease progression due to lower arachidonic acid levels [R].

  • Decreased risk of developing Type II Diabetes [R].

  • Decreased risk of developing Coronary artery disease (CAD) [R].

  • Decreased LDL cholesterol (bad cholesterol) levels [R].

  • Possible increased need for fish oil supplements to maintain healthy omega-3 fatty acid levels [R].

  • Decreased risk of developing gingivitis, or gum disease [R].

The G (major) allele is associated with:

  • Increased levels of arachidonic acid in the body [R]. Arachidonic acid is an Omega-6 polyunsaturated fatty acid.

  • Increased risk of prostate cancer and worse prognosis of disease progression due to higher arachidonic acid levels [R].

  • Increased risk of developing Type II Diabetes [R].

  • Increased risk of developing Coronary artery disease (CAD) [R].

  • Increased LDL cholesterol (bad cholesterol) levels [R].

  • Possible decreased need for fish oil supplements to maintain healthy omega-3 fatty acid levels [R].

  • Increased risk of developing gingivitis, or gum disease [R].

rs174537

Parent Gene: MYRF

Importance: 5
Less common allele: T = 30%
More common allele: G = 70%
My Genotype: Log In
Risk Allele: G, T, T, T, A, G

Disease/Trait: Colorectal Cancer

The G allele of rs174537 is reported to be associated with Colorectal Cancer (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Colorectal cancer.

Disease/Trait: Gamma-Linolenic Acid Measurement

The T allele of rs174537 is reported to be associated with Gamma-linolenic Acid Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid).

Disease/Trait: Trans Fatty Acid Measurement

The T allele of rs174537 is reported to be associated with Trans Fatty Acid Measurement (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Cis/Trans-18:2 Fatty Acid Measurement

The T allele of rs174537 is reported to be associated with Cis/trans-18:2 Fatty Acid Measurement (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174537 is reported to be associated with Blood Metabolite Measurement (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C36:2).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174537 is reported to be associated with Glycerophospholipid Measurement (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C36:2).

Disease/Trait: Crohn's Disease

The A allele of rs174537 is reported to be associated with Crohn's Disease (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Crohn's disease (EA).

Disease/Trait: Colorectal Cancer

The G allele of rs174537 is reported to be associated with Colorectal Cancer (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Colorectal cancer (East Asian).