The Minor "G" allele is associated with:

  • Lower production of LXR beta protein.
  • Increased protection against Type 2 diabetes (GG). 
  • Results are contrary to what one would expect based on the results in LXR in mice.
  • May regulate overall glucose homeostasis through other mechanisms and in other organs in humans (R).

The Major "C" allele is associated with:

  • Increased levels of LXR protein production (R).
  • Increased protection against tuberculosis (R).

rs17373080

Parent Gene: LXR

Importance: 3
Less common allele: G = 27%
More common allele: C = 73%
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