Mechanism:

  • Increased adiponectin levels (A) (R) (R). 
  • Lower production of adiponectin (G). 
  • Adiponectin levels may be related to race, where blacks are less affected by SNP than whites (R).

The A (minor) allele is associated with:

  • Higher rates of diabetes (R) when there is a family history of type 2 diabetes (R).
  • Higher BMI in Italian and French children (R). 
  • Higher rates of childhood obesity and related insulin resistance (studied European children) (R).
  • Fats from diet do not significantly affect adiponectin concentrations [R]
  • Protection from weight regain after a low calorie diet (R).
  • Lower BMI and lower obesity odds in combination with increased levels of monosaturated fatty acids (R).
  • Worse congestive heart failure prognosis if also diagnosed with diabetes (R).
  • Increased insulin sensitivity (studied in men) (R). 
  • Higher risk of polycystic ovary syndrome (R). 
  • lower insulin resistance (R). 

The G (major) allele is associated with:

  • Increased triglyceride levels and waist circumference with those with Type 1 Diabetes (R). 
  • Higher insulin resistance (R). 
  • Increased risk of metabolic syndrome (R). 
  • No relationship with increased heart attack or type 2 diabetes (Studied Italians) (R). 
  • Increased obesity traits (R). 
  • Increased lipids in blood (dyslipidemia) and high blood pressure (Family-based Arab study) (R). 

This SNP is associated with (unknown which allele):

  • Prognosis of end-stage renal disease in people with Type 1 Diabetes (R). 
  • Albuminuria levels (R). 
  • Obesity risks in Caucasians (R). 
  • Coronary heart disease (R).

rs17300539

Parent Gene: ADIPOQ

Importance: 4
Less common allele: A = 3%
More common allele: G = 97%
My Genotype: Log In
Risk Allele: G

Disease/Trait: Adiponectin Measurement

The G allele of rs17300539 is reported to be associated with Adiponectin Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Adiponectin levels in pregnancy (adjusted for BMI, height & mean arterial pressure).