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rs1611115 is linked to the DBH gene. It has a significant association with personality and mental health disorders. 

Mechanism:

  • Decreased levels of Dopamine-beta-Hydroxylase (T).
  • Normal levels of Dopamine-beta-Hydroxylase (C).

The Minor "T" allele is associated with:

  • Higher dopamine and lower norepinephrine because of lower DBH (Dopamine-beta-hydroxylase), which converts dopamine to norepinephrine (T) (R).
  • More neuroticism (TT) (R).
  • More novelty seeking (TT) (R).
  • More impulsivity (TT) (R).
  • More aggression (TT) (R).
  • Increased risk of adult ADHD (TT) (R).
  • Lower conscientiousness (TT) (R),

rs1611115

Parent Gene: DBH

Importance: 2
Less common allele: T = 21%
More common allele: C = 79%
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