rs1476413 is a SNP in the maternal MTHFR gene. It significantly interacts with maternal folate intake to decrease the risk of neural tube defects (NTDs).

The frequency of the ''T'' allele was greater in the CP + MR (cerebral palsy + mental retardation) patients than in the CP (cerebral palsy)- patients only and controls [R].

The TT genotype exhibited a marginally significant association with colorectal cancer (CRC) (OR = 1.56) [R]. 

Bladder cancer cases were also 60% less likely to be homozygotes for the ''T'' allele compared to controls (OR = 0.40) [R].

Mothers had a decreased risk of an neural tube defect (NTD)-affected pregnancy with low intake of folates and  in heterozygous compared to common homozygous mothers in the high folate intake group (GG vs AG; OR = 0.55, P = 0.15) [R].

 

rs1476413

Parent Gene: MTHFR

Importance: 2
Less common allele: T = 25%
More common allele: C = 75%
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