Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS


Mechanism:

  • Normal levels of Insulin growth factor-binding protein 3 (IGFBP3) in the body (GG) [R].
  • Normal levels of IGFBP3 in the body (G)
  • The A allele may be associated with lower IGFBP3 levels in the body. More research needs to be done to confirm this (A)
  • IGFBP3 binds insulin growth factors 1 and 2 (IGF-1, IGF-2) and acts as a main carrier of both factors through the bloodstream [R].

The Minor "A" allele is associated with:

  • Increased triglyceride levels [R].
  • Decreased High-density lipoprotein cholesterol (HDL) [R].
  • Lower HDL may lead to increased risk of cardiovascular disease [R].
  • Increased triglyceride and decreased HDL may lead to obesity [R].
  • Decreased muscle and limb development [R].
  • Clubfoot [R].

The Major "G" allele is associated with:

  • Decreased triglycerides and increased HDL, lowering the risk of cardiovascular disease and obesity [R][R][R][R].
  • Increased muscle and limb development and decreased the likelihood of clubfoot [R][R].

rs13223993

Parent Gene: IGFBP3
Importance: 3
Minor Allele: A = 30%
Major Allele: G = 70%
My Genotype: Log In