Mechanism:

  • Higher levels of C/EBP beta binding activity (TT)  [R]

  • Increased white matter brain volumes (T) [R]

  • Lower frontal and temporal (brain) white matter volumes (C) [R]

The “C” (minor) allele is associated with:

  • Higher Extraversion in the Big 5 Personality [R]

  • Slower processing speed [R]

  • Shorter attention span [R]

  • Poorer problem-solving skills [R]

  • Cannabis dependence [R]

  • Greater impairment of problem-solving skills with misuse of marijuana [R]

  • Higher level of total body fat and central fat deposition [R]

  • An increased schizophrenia risk with marijuana misuse [R]

The “T” allele is associated with:

  • Increased neural regeneration after injury [R]

  • Better memory [R]

  • Better learning ability [R]

This SNP is associated with (unknown which alleles):

  • Nicotine dependence (especially in women) [R]

rs12720071

Parent Gene: CNR1

Importance: 5
Less common allele: C = 9%
More common allele: T = 91%
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