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The G (major) allele is associated with:

  • GG=reduced enzyme activity by 51%, which converts beta-carotene to retinol [R].
  • Lower levels of retinol because it cannot be converted from beta carotene.
  • Retinol is essential for vision, so a decrease in this protein may reduce sight.

rs11645428

Parent Gene: BCO1

Importance: 3
Less common allele: A = 16%
More common allele: G = 84%
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