- Increased levels of DBH protein (G)
- Decreased levels of DBH protein (A)
- DBH converts dopamine to norepinephrine and the A allele is associated with lower levels of DBH [R]and therefore lower norepinephrine to dopamine ratios [R].
- Higher Dopamine, lower norepinephrine (A) [R].
- Lower Dopamine, higher norepinephrine (G) [R].
The Minor "G" allele is associated with:
- Individual differences in retention accuracy in a spatial working memory (match-to-sample) task but not with performance on a spatial attention task. (R)
- Increased risk of having Parkinsons Disease (R). Note: One study shows insignificant connections to PD (R).
- Increased risk of alcoholism (R).
- Methamphetamine psychosis, with more than a 2x greater chance of relapsing after going through complete remission (R)
- Alcoholism withdrawal symptoms begin 2 years after remission, significantly sooner than normal (R)
- Faster dependence on alcohol (GG) (R).
The Major "A" allele is associated with:
- Slightly increased risk of Schizophrenia (R).
- Hyperactive and oppositional characteristic traits (R).
- More accurate and speedier decision making when incorrect advice is given (R).
- Faster at verifying computer-generated recommendations (R).
- Increased likelihood of ADHD (R, R), especially for males (R).