Mechanism:

  • Normal levels of brain derived neurotrophic factor (BDNF) within the body (AA)
  • Normal levels of BDNF within the body (A)
  • Decreased levels of BDNF within the body (T) [R].
  • BDNF is essential in helping neurons survive in the body and encouraging the growth and development of new neurons. For these reasons, BDNF is very important in small developing children [R].

The T (minor) allele is associated with:

  • Decreased cognitive processing speed in the brain [R].
  • Attention Deficit Hyperactivity Disorder (ADHD) and worsening the symptoms of ADHD [R].
  • Decreased development of neural pathways in infants [R].
  • Behaviors similar to those found in subjects with Autism spectrum disorder (ASD) [R].
  • Facilitated development of ASD in children [R].
  • Increased social stress sensitivity [R]. This may lead to social anxiety.
  • Increased positive response to electroconvulsive therapy (ECT) in patients being treated for major depressive disorder (MDD) [R].
  • Increased weight gain during treatment with atypical antipsychotics in patients with schizophrenia [R].
  • Development of more severe forms of asthma [R].

The A (major) allele is associated with:

  • Increased cognitive processing speed in the brain [R].
  • Decreased risk of ADHD [R].
  • Decreased development of autism in infants and children [R].
  • Decreased risk of social anxiety [R].
  • Decreased response to ECT treatment in patients with MDD [R].
  • Decreased weight gain during treatment with atypical antipsychotic drugs [R].
  • Decreased development of severe asthma [R].
  • Higher risk of developing bipolar disorder and schizophrenia (AT)  [R]
  • Higher risk of developing attention deficit hyperactive disorder [R] (n=202 Korean girls)

This SNP is associated with (unknown  which alleles):

  • Neutralizing social stress [R]

  • Risk of severe asthma if asthma is independently attained [R] (n=3099 German children)

rs11030101

Parent Gene: BDNF

Importance: 4
Less common allele: T = 27%
More common allele: A = 73%
My Genotype: Log In