Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS


The Minor "T" allele is associated with:

  • Significantly increased the risk of developing autoimmune disease risk with each T allele. 

rs10484554

Parent Gene: HLA-C
Importance: 3
Minor Allele: T = 11%
Major Allele: C = 89%
My Genotype: Log In
Risk Allele: T, T, T

Disease/Trait: Psoriasis

The T allele of rs10484554 is reported to be associated with Psoriasis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Cutaneous psoriasis.

Reported risk allele frequency: None
Reported genes: HLA-C
Odds ratio: 3.304
Risk Allele: T (P=4.00*10-207)
Context: intron_variant
Study title: Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. (R)
Initial sample size: 1,363 European ancestry cases, 4,934 European ancestry controls
Replication sample size: up to 2,969 European ancestry cases, up to European ancestry 14,384 controls
Journal: Am J Hum Genet (R)
Year published: Nov. 28, 2015
Strength of evidence: Strong

Disease/Trait: Cutaneous Psoriasis Measurement

The T allele of rs10484554 is reported to be associated with Cutaneous Psoriasis Measurement. Your genotype was not identified for this SNP so we are unable to comment on your association with Cutaneous psoriasis.

Reported risk allele frequency: None
Reported genes: HLA-C
Odds ratio: 3.304
Risk Allele: T (P=4.00*10-207)
Context: intron_variant
Study title: Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. (R)
Initial sample size: 1,363 European ancestry cases, 4,934 European ancestry controls
Replication sample size: up to 2,969 European ancestry cases, up to European ancestry 14,384 controls
Journal: Am J Hum Genet (R)
Year published: Nov. 28, 2015
Strength of evidence: Strong

Disease/Trait: Aids

The T allele of rs10484554 is reported to be associated with Aids(R). Your genotype was not identified for this SNP so we are unable to comment on your association with AIDS progression.

Reported risk allele frequency: 13.00%
Reported genes: HLA-C
Risk Allele: T (P=6.00*10-8)
Context: intron_variant
Study title: Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (AS Genomewide Association Study 02). (R)
Initial sample size: 275 European ancestry seropositive non-progressors, 86 European ancestry seropositive rapid progressors, 1,352 European ancestry seronegative controls
Replication sample size: (see Fellay 2007)
Journal: J Infect Dis (R)
Year published: Jan. 1, 2009
Strength of evidence: Strong

Disease/Trait: Psoriasis

The T allele of rs10484554 is reported to be associated with Psoriasis(R). Your genotype was not identified for this SNP so we are unable to comment on your association with Psoriasis.

Reported risk allele frequency: 15.00%
Reported genes: HLA-C
Odds ratio: 2.8
Risk Allele: T (P=2.00*10-39)
Context: intron_variant
Study title: A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. (R)
Initial sample size: 218 European ancestry cases, 519 European ancestry controls
Replication sample size: 1,153 European ancestry cases, 1,217 European ancestry controls
Journal: PLoS Genet (R)
Year published: April 4, 2008
Strength of evidence: Strong