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Mechanism:

  • Encodes the 'nonsecretor' (se2 or sej) allele.  No expression of galactoside 2-alpha-L-fucosyltransferase enzyme (from this SNP) (T) [R].
  • Encodes the 'Secretor' allele...Expression of galactoside 2-alpha-L-fucosyltransferase enzyme (A).

The Minor "T" allele is associated with:

  • Innate resistance to norovirus GII.4 [R].

  • No Leb antigens in the Lewis blood group; only Lea [R].

  • Low levels of microbes in digestive system [R].

  • Higher risk of Crohn's disease [R].

  • Higher levels of serum vitamin B12 in bloodstream [R].

  • Elevated levels of tumor biomarkers [R].

  • Increased resistance to respiratory infections and HIV due to lack of antigens [R].

The Major "A" allele is associated with:

  • Producing a soluble form of the H-antigen, a precursor to the A and B antigens on red blood cells [R]

  • High number of Leb antigens in Lewis blood group (used to determine secretor status) [R]

This SNP is associated with (unknown which alleles):

  • Rs601338. Both SNPs together determines secretor status for certain populations. Populations of Japanese descent do not have this formation, so secretor status is determined by Rs1047781 alone. [R, R]

  • FUT1 gene: Another gene involved in producing the H antigen. If one fails the other makes up for it. [R]

  • FUT3 gene: Involved in producing the Lea antigen, a precursor to Leb. [R]

rs1047781

Parent Gene: FUT2

Importance: 5
Less common allele: T = 9%
More common allele: A = 91%
My Genotype: Log In
Risk Allele: T, C, T

Disease/Trait: Serum Carcinoembryonic Antigen Measurement

rs1047781 is associated with Serum Carcinoembryonic Antigen Measurement (R). It is reported to association with Elevated serum carcinoembryonic antigen levels. No specific risk allele was identified in the study.

Disease/Trait: Cancer Biomarker Measurement

The T allele of rs1047781 is reported to be associated with Cancer Biomarker Measurement (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Tumor biomarkers (CA19-9).

Disease/Trait: Psoriasis

The C allele of rs1047781 is reported to be associated with Psoriasis (R). Your genotype was not identified for this SNP so we are unable to comment on your association with Psoriasis.

Disease/Trait: Vitamin B12 Measurement

rs1047781 is associated with Vitamin B12 Measurement (R). It is reported to have a 70.21 pg/ml increase on Vitamin B12 levels. No specific risk allele was identified in the study.