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Mechanism:

  • Encodes the 'nonsecretor' (se2 or sej) allele.  No expression of galactoside 2-alpha-L-fucosyltransferase enzyme (from this SNP) (T) [R].
  • Encodes the 'Secretor' allele...Expression of galactoside 2-alpha-L-fucosyltransferase enzyme (A).

The Minor "T" allele is associated with:

  • Innate resistance to norovirus GII.4 [R].

  • No Leb antigens in the Lewis blood group; only Lea [R].

  • Low levels of microbes in digestive system [R].

  • Higher risk of Crohn's disease [R].

  • Higher levels of serum vitamin B12 in bloodstream [R].

  • Elevated levels of tumor biomarkers [R].

  • Increased resistance to respiratory infections and HIV due to lack of antigens [R].

The Major "A" allele is associated with:

  • Producing a soluble form of the H-antigen, a precursor to the A and B antigens on red blood cells [R]

  • High number of Leb antigens in Lewis blood group (used to determine secretor status) [R]

This SNP is associated with (unknown which alleles):

  • Rs601338. Both SNPs together determines secretor status for certain populations. Populations of Japanese descent do not have this formation, so secretor status is determined by Rs1047781 alone. [R, R]

  • FUT1 gene: Another gene involved in producing the H antigen. If one fails the other makes up for it. [R]

  • FUT3 gene: Involved in producing the Lea antigen, a precursor to Leb. [R]

rs1047781

Parent Gene: FUT2

Importance: 5
Less common allele: T = 9%
More common allele: A = 91%
My Genotype: Log In
Risk Allele: T, C, T