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rs1043618 is a SNP of the HSPA1A gene. It significantly contributes to the risk of developing coronary heart disease (CHD) [R]. 

''CC'' genotype was associated with significantly higher risk of coronary heart disease (CHD) when compared with ''GG'' genotype (OR = 1.56, P = 0.012) [R]. 

The ''GC'' genotype was found to be associated with noise-induced hearing loss (NIHL) susceptibility (adjusted OR = 2.634) [R]. 

The "C" allele showed strong association with long QT syndrome (LQTS) [R]. 

The ''C'' allele had an 86% reduced risk of high-altitude pulmonary edema (HAPE) (P=0.0009) [R].

The ''G'' alleles could contribute lesser to the risk of developing atherosclerosis [R].

In H1N1 infection, the ''C'' allele was associated with liver dysfunction. The ''C'' allele was also associated with longer MICU stay in patients with H1N1 infection [R].

In patients with severe trauma the ''C'' allele was found to be a risk factor for a higher incidence of liver failure and higher organ failure score [R].

 

rs1043618

Parent Gene: HSPA1L

Importance: 2
Minor Allele: C = 48%
Major Allele: G = 52%
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