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Mechanism:

  • A=increased plasma levels of Insulin-like Growth Factor Binding Protein-3 (IGFBP3) [R].

The "A" allele is associated with:

  • Reduced risk of breast cancer in European women, based on a study of both European and East Asian women [R]. These findings have not been replicated.

The “C” allele is associated with:

  • Increased risk of breast cancer in European women, based on a study of both European and East Asian women [R]. These findings have not been replicated.

rs1019731

Parent Gene: IGF1
Importance: 2
Minor Allele: A = 7%
Major Allele: C = 93%
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